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GNE may refer to:
- GNE (encyclopedia), a free content encyclopedia
- GNE (gene)
- Ganang language, spoken in Nigeria
- Genesis Energy Limited, a New Zealand energy company
- Go North East, an English bus operator
- UDP-N-acetylglucosamine 2-epimerase (hydrolysing)
| disambiguation page lists articles associated with the title GNE.
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